Glyco-gold nanoparticles: synthesis and applications

• Federica Compostella,
• Olimpia Pitirollo,
• Alessandro Silvestri and
• Laura Polito

Beilstein J. Org. Chem. 2017, 13, 1008–1021, doi:10.3762/bjoc.13.100

• : gold nanoparticles; glyco nanoparticles; glyconanomaterials; immunology; targeting; Introduction Carbohydrates are well recognized as crucial biomolecules for their capability to produce an enormous number of biocodes which are translated into their ability to promote or suppress a plethora of

• resulting biological processes [3][4]. The increasing ability to manipulate material at the nanosize allowed the development of many glyco nanoparticles helpful in a wide range of applications, from the drug delivery to the imaging [5][6][7]. Among the large number of nanomaterials, gold is one of the main

• exploited scaffolds for producing glyco nanoparticles [3][4]. First of all, gold is an extremely inert and biocompatible material. At nanosize, gold nanoparticles (AuNPs) are characterized by unique optical features which result extremely useful in many diagnosis and affinity studies or protocols. Moreover

New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin

• Otman Otman,
• Paul Boullanger,
• Eric Drockenmuller and
• Thierry Hamaide

Beilstein J. Org. Chem. 2010, 6, No. 58, doi:10.3762/bjoc.6.58

• polymer surfactants for the colloidal stabilization of polycaprolactone (PCL) nanoparticles. Preliminary studies towards the recognition of these glyco-nanoparticles by specific concanavalin A (con A) lectin have been carried out, which provided clear evidence for the presence of carbohydrate units on the